SLC14 family of facilitative urea transporters in GtoPdb v.2023.1
نویسندگان
چکیده
As a product of protein catabolism, urea is moved around the body and through kidneys for excretion. Although there experimental evidence concentrative transporters, these have not been defined at molecular level. The SLC14 family are facilitative allowing movement down its concentration gradient. Multiple splice variants transporters identified; UT-A in particular, cell-specific expression with functional impact [6, 1]. Topographical modelling suggests that majority 10 TM domains, glycosylated extracellular loop TM5/6, intracellular C- N-termini. UT-A1 variant, exceptionally, has 20 equivalent to combination UT-A2 UT-A3 variants.
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ژورنال
عنوان ژورنال: IUPHAR/BPS guide to pharmacology CITE
سال: 2023
ISSN: ['2633-1020']
DOI: https://doi.org/10.2218/gtopdb/f186/2023.1